Should I take my 2 week paid vacation, and then quit my job?

I'm sick of my job. I never take a day off, I work a lot more than everyone else here, and my boss doesn't appreciate it. Last year, I didn't use my vacation days at all, so the girl from human resources wrote me an e-mail remindng me I have my 2 week vacaction. I want to quit my job, should I take the 2 week vacation, and then come back and tell them I quit?